Scientist II, Precision Medicine TA at AbbVie — Waltham, MA

The Precision Medicine Immunology Department is seeking a highly motivated Scientist with a background in immunology or immuno-oncology and experience in single-cell or spatial genomics, molecular biology, and cell biology to join the Translational Research team. This individual will support clinical biomarker discovery by profiling clinical and preclinical samples using single-cell and spatial omics approaches to better understand drug mechanisms of action and pharmacodynamics, while helping drive data-informed patient selection strategies. The role will contribute to drug development programs across inflammatory and autoimmune disease areas, including Dermatology, Gastroenterology, Rheumatology, and Fibrosis, spanning late-stage discovery through clinical trials. The successful candidate will join a growing translational research group and collaborate with cross-functional teams both internally and externally.

Key Responsibilities

• Independently lead the design, execution, and analysis of complex genomic profiling experiments, including scRNA-Seq, CITE-Seq, snRNA-Seq, and spatial transcriptomics/proteomics.
• Proactively identify technical artifacts, interpret quality control results, optimize assay performance, and ensure high quality and reproducible data delivery on timely deadlines.
• Stay at the forefront of the single-cell and spatial genomics field by surveying, evaluating, testing and validating novel scientific methodologies.
• Present work plans and acquired data clearly and precisely to cross-functional stakeholders through formal written reports and verbal updates.
• B.S. & typically 7+ years, M.S. & typically 5+ years of relevant industrial biotechnology experience in Immunology, cell & molecular biology, pharmacology, pathology, or other relevant biological sciences.
• Broad technical expertise in molecular and cell biology assays, with specialization in scRNA-seq, CITE-seq, and snRNA-seq across blood and tissue samples.
• Expertise in executing spatial omics experiments using CosMx, Xenium, and Visium platforms, integrated with deep expertise in molecular pathology techniques such as IHC and ISH.
• Strong organizational skills, with a demonstrated ability to prioritize tasks and allocate resources to meet aggressive timelines.
• A robust track record of scientific writing, ensuring high-quality documentation and verbal reporting of technical findings.

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible to participate in our short-term incentive programs.